05580733 is referenced by 126 patents and cites 20 patents.

Method for analyzing a nucleic acid molecule, without fragmenting the molecule, by vaporizing a mixture of the molecule and a matrix by illuminating the mixture with visible laser light absorbed by the matrix and not by the nucleic acid molecule. The method is useful for determining the nucleotide sequence of a polynucleotide by using mass spectrometry to determine the molecular weights of individual single-stranded nucleic acid molecules in a population including a plurality of single-stranded nucleic acid molecules generated from the polynucleotide, each molecule having a different molecular weight, and one defined terminus and one variable terminus which terminates at a specific nucleotide.

Title
Vaporization and sequencing of nucleic acids
Application Number
648282
Publication Number
5580733
Application Date
September 6, 1994
Publication Date
December 3, 1996
Inventor
Louis J Romano
Detroit
MI, US
Robert J Levis
Grosse Pointe Park
MI, US
Agent
Reising Ethington Barnard & Perry
Assignee
Wayne State University
MI, US
IPC
B01D 59/44
G01N 33/48
C12P 19/34
C12Q 1/68
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