05578325 is referenced by 164 patents and cites 4 patents.

Injectable particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified as necessary to achieve variable release rates or to target specific cells or organs as desired. The injectable particles can include magnetic particles or radiopaque materials for diagnostic imaging, biologically active molecules to be delivered to a site, or compounds for targeting the particles. Biodistribution experiments indicate that the injectable particles have a prolonged half-life in the blood compared to particles not containing poly(alkylene glycol) moieties on the surface.

Title
Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
Application Number
96370
Publication Number
5578325
Application Date
June 24, 1994
Publication Date
November 26, 1996
Inventor
Robert S Langer
Newton
MA, US
Maria T Peracchia
Parma
IT
Yoshiharu Minamitake
Ota
JP
Ruxandra Gref
Nancy
FR
Abraham J Domb
Efrat
IL
Agent
Arnall Golden & Gregory
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61K 47/30
A61K 31/74
A61K 9/48
A61K 9/50
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