05576207 is referenced by 32 patents and cites 1 patents.

A composition which comprises an animal cell population, and which contains immature animal cells. The immature animal cells are characterized by expression of alpha-fetoprotein or lack of essential expression of alpha-fetoprotein and albumin, and at least a portion of said immature animal cells or at least a portion of the progeny of said immature cells is capable of differentiating into cells which express albumin. The cell population is cultured under conditions which result in expansion of the cells. Expansion of the cells may be achieved by culturing the cells in the presence of an extracellular matrix and liver stromal cells; and preferably in the presence of growth factors. Such cells may be used for liver transplantation, artificial livers, and for toxicology and pharmacology studies. Such cells may also be genetically engineered to express proteins or polypeptides of interest.

Title
Method of expanding hepatic precursor cells
Application Number
741128
Publication Number
5576207
Application Date
June 24, 1994
Publication Date
November 19, 1996
Inventor
Andreas Ochs
Bronx
NY, US
Maria Agelli
Summit
NJ, US
Lola M Reid
Chapel Hill
NC, US
Agent
Amster Rothstein & Ebenstein
Assignee
Albert Einstein College of Medicine of Yeshiva University a Division of Yeshiva University
NY, US
IPC
C12N 5/08
C12N 5/06
C12N 5/00
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