05565555 is referenced by 110 patents and cites 13 patents.

Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses, A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.

Title
Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues
Application Number
248517
Publication Number
5565555
Application Date
February 21, 1995
Publication Date
October 15, 1996
Inventor
Chris A Buhr
Daly City
CA, US
Brian C Froehler
Belmont
CA, US
Agent
Mark L Bosse
Assignee
Gilead Sciences
CA, US
IPC
C07H 19/16
C07H 19/06
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