05565519 is referenced by 102 patents and cites 57 patents.

Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantially nonfibrillar form at pH 7 and is preferably succinylated or methylated collagen. The synthetic hydrophilic polymer is preferably an activated polymeric glycol, most preferably, a di- or multifunctionally activated polyethylene glycol. Materials and devices formed with the chemically modified collagen-synthetic polymer conjugates have good optical clarity, mechanical strength, and moldability.

Title
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
Application Number
274071
Publication Number
5565519
Application Date
November 3, 1993
Publication Date
October 15, 1996
Inventor
Frank A DeLustro
Belmont
CA, US
George H Chu
Cupertino
CA, US
Prema R Rao
Los Gatos
CA, US
Woonza M Rhee
Palo Alto
CA, US
Agent
Shirley L Church
Kathi Rafayko
Assignee
Collagen Corporation
CA, US
IPC
C08G 63/91
C08G 63/48
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