05565350 is referenced by 346 patents and cites 5 patents.

The present invention concerns a polynucleotide having both ribonucleotides and deoxyribonucleotides in a first strand and solely deoxyribonucleotides in a second strand; wherein the strands are Watson-Crick paired and are linked by an oligonucleotide so that the polynucleotide has at most a single 3' and a single 5' end. These ends can be ligated so that the polynucleotide is a single continuous circular polymer. The polynucleotide can be used to induce specific alterations in targeted genes.

Title
Compounds and methods for site directed mutations in eukaryotic cells
Application Number
164303
Publication Number
5565350
Application Date
December 9, 1994
Publication Date
October 15, 1996
Inventor
Eric B Kmiec
Malvern
PA, US
Agent
Pennie & Edmonds
Assignee
Thomas Jefferson University
PA, US
IPC
C07H 21/00
C12N 15/63
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