05552422 is referenced by 167 patents and cites 14 patents.

The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

Title
Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
Application Number
8/371179
Publication Number
5552422
Application Date
January 11, 1995
Publication Date
September 3, 1996
Inventor
Zhaoyin Wang
Pierrefonds
CA
Michel Therien
Laval
CA
Patrick Roy
Dollard des Ormeaux
CA
Chun Sing Li
Dollard des Ormeaux
CA
Yves LeBlanc
Kirkland
CA
Cheuk K Lau
Ile Bizard
CA
Jacques Y Gauthier
Laval
CA
Agent
David L Rose
Curtis C Panzer
Assignee
Merck Frosst Canada
CA
IPC
A61K 31/435
C07D 487/04
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