05550111 is referenced by 244 patents and cites 7 patents.

Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.

Title
Dual action 2,5-oligoadenylate antiviral derivatives and uses thereof
Application Number
629660
Publication Number
5550111
Application Date
November 3, 1994
Publication Date
August 27, 1996
Inventor
Wolfgang Pfleiderer
Konstanz
DE
Robert J Suhadolnik
Roslyn
PA, US
Agent
Seidel Gonda Lavorgna & Monaco P C
Assignee
Temple University Of The Commonwealth System Of Higher Education
PA, US
IPC
C07H 21/00
A61K 31/70
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