05547841 is referenced by 35 patents and cites 6 patents.

The invention relates to an in vitro method of screening for drugs, potentially useful for treatment of Alzheimer's Disease. The method involves contacting a drug with a host transformed with a DNA construct which contains at least the DNA coding for human A4-amyloid peptide and overexpresses the peptide and then detecting the prevention of production or increased degradation of the A4-peptide due to the drug.

Title
In vitro method for screening for drugs that inhibit production or degradation of human A4-amyloid
Application Number
105752
Publication Number
5547841
Application Date
December 15, 1992
Publication Date
August 20, 1996
Inventor
Sayeeda Zain
Pittsford
NY, US
Charles A Marotta
Cambridge
MA, US
Agent
Sterne Kessler Goldstein & Fox P L L C
Assignee
University of Rochester
NY, US
The McLean Hospital Corporation
MA, US
IPC
G01N 33/543
G01N 33/53
C12Q 1/68
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