05545618 is referenced by 251 patents and cites 5 patents.

The invention provides effective analogs of the active GLP-1 peptides, 7-34, 7-35, 7-36, and 7-37, which have improved characteristics for treatment of diabetes Type II. These analogs have amino acid substitutions at positions 7-10 and/or are truncated at the C-terminus and/or contain various other amino acid substitutions in the basic peptide. The analogs may either have an enhanced capacity to stimulate insulin production as compared to glucagon or may exhibit enhanced stability in plasma as compared to GLP-1 (7-37) or both. Either of these properties will enhance the potency of the analog as a therapeutic. Analogs having D-amino acid substitutions in the 7 and 8 positions and/or N-alkylated or N-acylated amino acids in the 7 position are particularly resistant to degradation in vivo.

Title
GLP-1 analogs useful for diabetes treatment
Application Number
468736
Publication Number
5545618
Application Date
December 10, 1993
Publication Date
August 13, 1996
Inventor
Svetlana Mojsov
504 E. 63rd St., New York, 10021
NY, US
Joanne B Mallory
199 Acalanes, Apt. 3, Sunnyvale, 94086
CA, US
Joel F Habener
217 Plymouth Rd., Newton Highlands, 02161
MA, US
Douglas I Buckley
215 Brookward Rd., Woodside, 94062
CA, US
Agent
Morrison & Foerster
IPC
C07K 7/10
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