05527899 is referenced by 127 patents and cites 2 patents.

Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleotide duplex. The inverted polarity also stabilizes the single-strand oligonucleotides to exonuclease degradation.

Title
Oligonucleotides with inverted polarity
Application Number
425803
Publication Number
5527899
Application Date
November 16, 1993
Publication Date
June 18, 1996
Inventor
Brian Froehler
Belmont
CA, US
Agent
Mark L Bosse
Assignee
Gilead Sciences
CA, US
IPC
C07H 21/00
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