05527545 is referenced by 12 patents and cites 12 patents.

Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coats of polymeric hydrophilic and hydrophobic materials, at least the innermost of said coats imparting controlled-release properties to said naproxen according to a predetermined release profile, and at least the outermost of said coats imparting resistance to dissolution in gastric fluids; and (c) a liquid administration vehicle. This composition enables the oral administration of naproxen as a single daily dose the adjustment of the dosage to a patient's requirements, and avoids detrimental effects of prolonged contact of naproxen with the gastric mucosa thus aiding oral intake and minimizing the drug's typical side effects.

Title
Liquid-suspension controlled-release pharmaceutical composition
Application Number
408755
Publication Number
5527545
Application Date
December 10, 1993
Publication Date
June 18, 1996
Inventor
Ettore Bilato
Padova
IT
Giuseppe Bottoni
Bergamo
IT
Giancarlo Santus
Milan
IT
Agent
Darby & Darby
Assignee
Recordati Chemical and Pharmaceutical Company
CH
IPC
A61K 9/22
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