05512055 is referenced by 246 patents and cites 14 patents.

Devices are provided having a polymer coating incorporating compounds inhibiting inflammation and infection, along with subsequent tissue growth onto and around the device. Preferred embodiments include catheters, tubes, and implants that abut tissue following implantation into the body, especially for use in the naso-oto-pharyngeal areas of the body, where localized chronic infection/inflammation of the tissues surrounding the implant may be decreased by sustained release of antibiotics, antifungals, antivirals, anti-inflammatories, and other compounds, such as anticoagulants and anesthetics. Preferred polymeric coatings are thin, well adhered to the underlying device, and formed of a biocompatible, non-bioerodible polymer such as polyurethane or ethylene vinyl acetate. The drug is incorporated either by solvent casting or by absorption into the solidified polymer. The drug incorporated polymer can also be used to form devices, or portions of devices, for implantation.

Title
Anti-infective and anti-inflammatory releasing systems for medical devices
Application Number
661699
Publication Number
5512055
Application Date
September 30, 1994
Publication Date
April 30, 1996
Inventor
Manoj Maniar
Baltimore
MD, US
Andrew S T Haffer
Baltimore
MD, US
Alain Shikani
Baltimore
MD, US
Abraham J Domb
Baltimore
MD, US
Agent
Leonard Bloom
Assignee
Leonard Bloom
MD, US
IPC
A61M 5/32
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