05508039 is referenced by 9 patents and cites 38 patents.

The present invention is directed to the transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device (10) comprising a matrix (12) adapted to be placed in melatonin- and permeation enhancer-transmitting relation with the skin site (18). The matrix (12) contains sufficient amounts of a permeation enhancer and of melatonin, in combination, to continuously administer to the skin (18) for a predetermined period of time the melatonin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of melatonin together with a skin permeation-enhancing amount of a suitable permeation enhancer. The invention further includes methods for time- and rate-patterned transdermal delivery of melatonin to simulate the natural circadian rhythmic profile of melatonin in mammals.

Title
Controlled transdermal administration of melatonin
Application Number
779215
Publication Number
5508039
Application Date
June 13, 1994
Publication Date
April 16, 1996
Inventor
Nieves M Crisologo
Sunnyvale
CA, US
Su I Yum
Los Altos
CA, US
Lina T Taskovich
Palo Alto
CA, US
F Eugene Yates
Pacific Palisades
CA, US
Agent
Edward L Mandell
Steven F Stone
Michael J Rafa
Assignee
ALZA Corporation
CA, US
IPC
A61K 31/40
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