05506206 is referenced by 67 patents and cites 7 patents.

Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more permeable. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose desired destination is the cerebrospinal fluid compartment of the brain. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive at this destination.

Title
Increasing blood-brain barrier permeability with permeabilizer peptides
Application Number
512913
Publication Number
5506206
Application Date
September 13, 1993
Publication Date
April 9, 1996
Inventor
Bernard Malfroy Camine
Arlington
MA, US
Gary F Musso
Hopkinton
MA, US
John W Kozarich
Cambridge
MA, US
Agent
Hamilton Brook Smith & Reynolds
Assignee
Alkermes
MA, US
IPC
C07K 7/02
A61K 38/08
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