05500362 is referenced by 339 patents and cites 15 patents.

The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention also relates to the increased ADCC and CDC cytolytic activities of the chimeric antibody, methods of production by recombinant DNA techniques, and uses.

Title
Chimeric antibody with specificity to human B cell surface antigen
Application Number
16202
Publication Number
5500362
Application Date
March 5, 1991
Publication Date
March 19, 1996
Inventor
Jeffrey A Ledbetter
Seattle
WA, US
Alvin Y Liu
Santa Monica
CA, US
Randy R Robinson
Los Angeles
CA, US
Agent
Sterne Kessler Goldstein & Fox
Assignee
XOMA Corporation
CA, US
IPC
G01N 33/574
C07K 16/30
A61K 39/395
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