05487739 is referenced by 166 patents and cites 43 patents.

Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a debilitating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the distal end of the cannula (20b). Once the vehicle (40) is positioned near the distal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).

Title
Implantable therapy systems and methods
Application Number
121626
Publication Number
5487739
Application Date
June 2, 1995
Publication Date
January 30, 1996
Inventor
Nicholas F Warner
Belmont
MA, US
Alfred V Vasconcellos
Cranston
RI, US
Paul R Sanberg
Greenwich
RI, US
Anne M Rathbun
Providence
RI, US
Paul J Mulhauser
New York
NY, US
John G Moldauer
Brooklyn
NY, US
Moses Goddard
Tiverton
RI, US
Patrick Aebischer
Barrington
RI, US
Agent
Fish & Neave
Agent
Barbara A Ruskin
Ivor R Elrifi
Assignee
Brown University Research Foundation
RI, US
IPC
A61F 2/04
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