05486359 is referenced by 515 patents and cites 13 patents.

Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. "mesenchymal stem cells" or "hMSCs"), and characterization of and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.

Title
Human mesenchymal stem cells
Application Number
34272
Publication Number
5486359
Application Date
February 8, 1994
Publication Date
January 23, 1996
Inventor
Stephen E Haynesworth
Cleveland Heights
OH, US
Arnold I Caplan
Cleveland Heights
OH, US
Agent
Elliot M Olstein
Charles J Herron
Assignee
Osiris Therapeutics
OH, US
IPC
C12N 5/08
C12N 5/00
A61K 35/12
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