05480883 is referenced by 166 patents and cites 13 patents.

This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.

Title
Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
Application Number
698420
Publication Number
5480883
Application Date
December 10, 1993
Publication Date
January 2, 1996
Inventor
Paul E Persons
King of Prussia
PA, US
Martin P Maguire
Mont Clare
PA, US
Michael R Myers
Reading
PA, US
Alfred P Spada
Lansdale
PA, US
Agent
Raymond S Parker III
Martin F Savitzky
James A Nicholson
Assignee
Rhone Poulenc Rorer Pharmaceuticals
PA, US
IPC
C07D 241/54
C07D 241/52
A61K 31/535
A61K 31/495
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