05478577 is referenced by 261 patents and cites 3 patents.

Patients are treated with 24-hour oral sustained release opioid formulations which upon administration quickly release an effective portion of the opioid contained therein such that there is an initially more rapid opioid release so that the minimum effective analgesic concentration of the opioid can be more quickly achieved. In the method, the formulations are designed to provide a relatively large peak to trough concentration of the opioid, rather than a flattened serum concentration curve.

Title
Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
Application Number
8/156468
Publication Number
5478577
Application Date
November 23, 1993
Publication Date
December 26, 1995
Inventor
Robert Kaiko
Weston
CT, US
Paul Goldenheim
Wilton
CT, US
Richard Sackler
Greenwich
CT, US
Agent
Steinberg Raskin & Davidson
Assignee
Euroceltique
LU
IPC
A61K 9/14
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