An applicator for suturing openings such as puncture sites in anatomical tissue applies a suture tie device having at least two outwardly turned hooks to penetrate the tissue proximate the opening. A stem, and a plurality of legs extending distally and radially outward from the stem, support the hooks and together with a collar movable along the stem and legs allow the hooks to be gathered radially inward after penetrating the tissue. The suture tie device can be disposed within a tubular housing dimensioned to fit within an endoscopic portal or cannula or for insertion directly through the opening in the anatomical cavity. A rod is disposed within the housing and connected to a proximal end of the stem of the suture tie device. An elongate tubular member is disposed between an inner circumference of the tubular housing and the rod proximally of the collar to move the collar along the stem and to gather the plurality of legs radially inward.