05472954 is referenced by 71 patents and cites 24 patents.

The invention provides a method for enhancing the complexation of a cyclodextrin with a lipophilic and/or water-labile active ingredient which is a drug, cosmetic additive, food additive or agrochemical, comprising combining from about 0.1 to about 70% (weight/volume) of a cyclodextrin, from about 0.001 to about 5% (weight/volume) of a pharmacologically inactive water-soluble polymer acceptable for use in a pharmaceutical, cosmetic, food or agricultural composition, and said lipophilic and/or water-labile active ingredient in an aqueous medium, the polymer and cyclodextrin being dissolved in the aqueous medium before the active ingredient is added, the aqueous medium which comprises the polymer and cyclodextrin being maintained at from about 30.degree. to 150.degree. C. for a period of from about 0.1 to about 100 hours before, during and/or after the active ingredient is added, optionally followed by removal of water. Related methods, co-complexes of active ingredient/cyclodextrin/polymer, pharmaceutical, cosmetic, food and agricultural compositions and cyclodextrin/polymer complexing agents are also provided.

Title
Cyclodextrin complexation
Application Number
912853
Publication Number
5472954
Application Date
May 11, 1994
Publication Date
December 5, 1995
Inventor
Thorsteinn Loftsson
Reykjavik
IS
Agent
Burns Doane Swecker & Mathis
Assignee
Cyclops h f
IS
IPC
C08B 37/16
A61K 31/735
A61K 47/48
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