05472943 is referenced by 135 patents and cites 4 patents.

This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously attenuating development of physical dependence, tolerance and other undesirable side-effects caused by the chronic administration of said bimodally-acting opioid agonists comprising the co-administration of a bimodally-acting opioid agonist which activates inhibitory opioid receptor-mediated functions of neurons in the nociceptive (pain) pathways of the nervous system and an opioid receptor antagonist which selectively inactivates excitatory opioid receptor-mediated side-effects caused by said bimodally-acting opioid agonists. This invention further relates to a method of detoxifying and treating opiate addicts utilizing said opioid receptor antagonists, as well as to a composition comprising an excitatory opioid receptor antagonist of the invention and a bimodally-acting opioid agonist.

Title
Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists
Application Number
947690
Publication Number
5472943
Application Date
July 27, 1993
Publication Date
December 5, 1995
Inventor
Ke fei Shen
Flushing
NY, US
Stanley M Crain
Leonia
NJ, US
Agent
Amster Rothstein & Ebenstein
Assignee
Albert Einstein College of Medicine of Yeshiva University
NY, US
IPC
A61K 31/44
View Original Source