05462990 is referenced by 256 patents and cites 100 patents.

Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

Title
Multifunctional organic polymers
Application Number
598880
Publication Number
5462990
Application Date
October 5, 1993
Publication Date
October 31, 1995
Inventor
Amarpreet Sawhney
Newton
MA, US
Sanghamitra Chowdhury
Round Rock
TX, US
Paul D Drumheller
Austin
TX, US
Jennifer L Hill West
Austin
TX, US
Donald Elbert
Austin
TX, US
Jeffrey A Hubbell
Austin
TX, US
Agent
Patrea L Pabst
Assignee
Board of Regents The University of Texas System
TX, US
IPC
C08L 1/00
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