An endoscope cover with a channel covers at least an inserted portion of an endoscope. The endoscope cover has a treatment tool channel into which a treatment tool is inserted and incorporates a treatment tool raising device for moving, to a predetermined position, the treatment tool inserted into the treatment tool channel and protruding from a distal end portion of the treatment tool channel. The endoscope cover includes an endoscope operating portion fixing port portion provided at a proximal end portion of an inserted portion covering portion which covers the inserted portion of the endoscope. The port portion fixes an operating portion of the endoscope inserted into the inserted portion covering portion. A treatment tool raising device operating member connected to the treatment tool raising device for operating the treatment tool raising device is disposed in the endoscope operating portion fixing port portion.