05458140 is referenced by 356 patents and cites 5 patents.

A method of enhancing the permeability of the skin or mucosa to an analyte for diagnostic purposed is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from low to high develops a local pressure gradient directed out of the body, thus permitting analytes in the body to traverse the skin and be collected and measured outside the body. The concentration of an analyte in the body is preferably determined by enhancing the permeability of the skin or other biological membrane optionally with a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient out of the body, collecting the analyte, and utilizing the analyte collection data calculating the concentration of the analyte in the body.

Title
Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
Application Number
8/152442
Publication Number
5458140
Application Date
November 15, 1993
Publication Date
October 17, 1995
Inventor
Robert S Langer
Newton
MA, US
Joseph Kost
Omer
IL
Deborah A Eppstein
Salt Lake City
UT, US
Jonathan A Eppstein
Atlanta
GA, US
Agent
Thorpe North & Western
Assignee
Non Invasive Monitoring Company
GA, US
IPC
A61B 5/00
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