05455175 is referenced by 147 patents and cites 21 patents.

A thermal cycling device having a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such a the DNA polymerase chain reaction. Biological samples are placed in glass microcapillary tubes and then located inside the sample chamber. A programmable controller regulates the temperature of the sample inside the sample chamber. Once a heating cycle is completed, the controller opens a door to the chamber for venting hot air out and cool ambient air is moved in. Temperature versus time profiles corresponding to optimum denaturation, annealing and elongation temperatures for amplification of DNA are achievable by the present invention.

Title
Rapid thermal cycling device
Application Number
534029
Publication Number
5455175
Application Date
January 10, 1994
Publication Date
October 3, 1995
Inventor
Kirk M Ririe
Idaho Falls
ID, US
David R Hillyard
Salt Lake City
UT, US
Carl T Wittwer
Salt Lake City
UT, US
Agent
Thorpe North & Western
Assignee
University of Utah Research Foundation
UT, US
IPC
C12M 1/34
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