A cam-locking orthopedic fixation device for anchoring a bone graft in a bore formed in a bone mass. The device has a head, a nose remote from the head, and a body, extending between the head and the nose, with a series of threaded crests only partially circumferentially surrounding the body. At least one side of the body is smooth and free of thread crests. The device is inserted into the space between a bone graft and a wall of the bore so that the side free of threads slides against bone. Upon complete insertion, a driving tool is coupled to the inserted head of the device. The device is then rotated so that threads cut into bone of both the graft and the bore thereby providing an interference fit between the walls of the bore and the bone graft that resists withdrawal of the bone graft from the bore.