05447724 is referenced by 466 patents and cites 40 patents.

A medical device and a method for its manufacture. The function of the medical device requires exposure of the device to the tissue of a patient. The device has a tissue-exposed portion constructed to release an agent that inhibits adverse reaction to the presence of the device defined by a polymeric surface-layer overlying in a supported manner a polymer defining a reservoir. The reservoir incorporates the agent in a manner that permits substantially free outward release of the agent from the reservoir and the overlying layer defines metering outward passages constructed to control the outward migration of the agent to enable prolonged release of the agent from the surface of the medical device to prevent the adverse reaction due to the presence of the device.

Title
Medical device polymer
Application Number
525339
Publication Number
5447724
Application Date
November 15, 1993
Publication Date
September 5, 1995
Inventor
Carol L Raleigh
Weston
MA, US
M Joshua Tolkoff
Brookline
MA, US
Michael N Helmus
Worcester
MA, US
Agent
Fish & Richardson
Assignee
Harbor Medical Devices
NH, US
IPC
A61M 5/32
A01N 1/02
A61F 2/04
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