05445611 is referenced by 328 patents and cites 11 patents.

A method of enhancing the permeability of the skin or mucosa to a biologically active permeant or drug is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from high to low develops a local pressure gradient directed into the body, thus permitting permeant to traverse the skin or mucosa. The enhanced delivery is preferably accomplished using a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient into the body. The method is also useful as a means for application of a tattoo by noninvasively delivering a pigment through the skin surface.

Title
Enhancement of transdermal delivery with ultrasound and chemical enhancers
Application Number
8/152174
Publication Number
5445611
Application Date
December 8, 1993
Publication Date
August 29, 1995
Inventor
Deborah A Eppstein
Salt Lake City
UT, US
Jonathan A Eppstein
Atlanta
GA, US
Agent
Thorpe North & Western
Assignee
Non Invasive Monitoring Company
GA, US
IPC
A61M 37/00
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