05443791 is referenced by 318 patents and cites 30 patents.

A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for programming and editing. A gauge block registered on the worksurface provides for calibration using the sensing tip, and register cavities on the worksurface provide for modular stations. There is a wash station fop the pipette tip on the worksurface. An automated laboratory based on the liquid-handling system has heating and cooling and a sealable incubation station as well as a magnetic separation station. Methods are disclosed using the apparatus to convey droplets of liquid, to aspirate with minimum tip contamination, to mix liquids in containers, and to validate the worksurface. A duck-billed closure is disclosed for minimizing evaporation and cross-contamination during processing, and is a part of a container disclosed for storing and transporting liquids.

Title
Automated molecular biology laboratory
Application Number
505626
Publication Number
5443791
Application Date
August 7, 1992
Publication Date
August 22, 1995
Inventor
Norman M Whiteley
San Carlos
CA, US
Chen Hanson Ting
San Mateo
CA, US
John Shigeura
Fremont
CA, US
Lincoln J McBride
Belmont
CA, US
William J Mordan
Mountain View
CA, US
Michael L Metzker
San Bruno
CA, US
Paul E Mayrand
Pacifica
CA, US
Douglas H Keith
Oakland
CA, US
Melvyn N Kronick
Palo Alto
CA, US
Eric Lachenmeier
Cupertino
CA, US
Louis B Hoff
Belmont
CA, US
Marianne Hane
Burlingame
CA, US
Harry A Guiremand
Half Moon Bay
CA, US
George S Golda
El Granada
CA, US
John A Bridgham
Hillsborough
CA, US
Thomas Brennan Marquez
Sunnyvale
CA, US
G Richard Cathcart
San Carlos
CA, US
Agent
Joseph H Smith
Donald R Boys
Assignee
Perkin Elmer Applied Biosystems Division
CA, US
IPC
G01N 21/11
G01N 1/10
G01N 35/08
G01N 21/01
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