05441870 is referenced by 130 patents and cites 6 patents.

Processing of .beta.-amyloid precursor protein (.beta.APP) is monitored by detecting the secretion of a soluble .beta.APP fragment resulting from cleavage of .beta.APP at the amino-terminus of .beta.-amyloid peptide. In vivo monitoring of secretion of the .beta.APP fragment may be monitored for diagnosis and prognosis of Alzheimer's disease and other .beta.-amyloid-related diseases, while in vitro monitoring of such secretion from cultured cells may be monitored to identify inhibitors of .beta.-amyloid production. The .beta.APP fragment may be detected using antibodies and other specific binding substances which recognize a carboxy-terminal residue on the fragment.

Title
Methods for monitoring cellular processing of .beta.-amyloid precursor protein
Application Number
868949
Publication Number
5441870
Application Date
October 26, 1992
Publication Date
August 15, 1995
Inventor
Lawrence C Fritz
San Francisco
CA, US
Dale B Schenk
Pacifica
CA, US
Peter A Seubert
South San Francisco
CA, US
Agent
Townsend and Townsend and Crew
Assignee
Eli Lilly and Company
IN, US
Athena Neurosciences
CA, US
IPC
G01N 33/53
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