An integrated blood treatment fluid module is provided having particular multi-function application in the treatment of renal failure. The module comprises a support member, a blood treatment device mounted to the support member, and multiple fluid circuits, wherein a plurality of the fluid circuits are interconnected to the support member and at least one of the fluid circuits is fluidly connected to the blood treatment device. At least two of the fluid circuits are interconnected with the support member so as to have a portion of each disposed in a U-shape, each U-shape portion extending in a different direction, for selective positioning about a corresponding peristaltic pump of a blood treatment apparatus. For renal treatment applications, the blood conditioning device may be a hemofiltration device, hemodialysis device or high-flux dialyzer. In such applications, a blood supply circuit is fluidly connected to a blood input port of the blood treatment device, a blood return circuit is fluidly connected to a blood output port of the blood treatment device, and a waste fluid circuit is fluidly connected to a waste output port of the blood treatment device. A treatment fluid circuit is also fluidly connected to a treatment fluid input port of the blood treatment device. A replacement fluid circuit can be fluidly connected with one of either the blood supply circuit or blood return circuit, and an anticoagulant fluid circuit can be fluidly interconnected to the blood supply circuit.