05439686 is referenced by 192 patents and cites 28 patents.

In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.

Title
Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
Application Number
8/23698
Publication Number
5439686
Application Date
February 22, 1993
Publication Date
August 8, 1995
Inventor
Kenneth S Suslick
Champaign
IL, US
Mark W Grinstaff
Pasadena
CA, US
Paul A Sandford
Los Angeles
CA, US
Patrick Soon Shiong
Los Angeles
CA, US
Neil P Desai
Los Angeles
CA, US
Agent
Stephen E Pretty Schroeder Brueggemann & Clark Reiter
Assignee
VivoRx Pharmaceuticals
CA, US
IPC
A61K 9/48
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