Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction United States Patent 05437291

05437291 is referenced by 230 patents and cites 13 patents.

Direct injection of sphincteric botulinum toxin is disclosed as an effective, safe and simple method of treatment for disorders of gastrointestinal muscle or smooth muscles elsewhere in the body, with results that appear to be sustained for several months. Muscle disorders which are suitable for such treatment include achalasia, isolated disorders of the lower esophageal sphincter, gastroparesis, hypertrophic pyloric stenosis, sphincter of Oddi dysfunction, short-segment Hirschsprung's, anal fissure, hemorrhoids, proctalgia fugax, irritable bowel syndrome, disorders of the upper esophageal sphincter, vasospastic disorders, and disorders of uterine and bladder spasm. Devices suitable for delivering this therapy are also disclosed.

Title
Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
Application Number
8/112088
Publication Number
5437291
Application Date
August 26, 1993
Publication Date
August 1, 1995
Inventor
Anthony N Kalloo
10708 Forestgate Pl., Glenndale, 20769
MD, US
Pankai J Pasricha
5007 Southern Star Ter., Columbia, 21044
MD, US
IPC
A61B 19/00
View Original Source

Citations: 230 (view full list)

  1. Eric First, M.D.
    Eric R First: toxin treatment for kinesia. Allergan, Claude L Nassif, Stephen Donovan, Martin A Voet, September 18, 2007: US07270287 (14 worldwide citation)
  2. Eric First, M.D.
    Eric R First: Botulinum toxin therapy for skin disorders. Allergan, Hal Gibson, Debra Condino, November 1, 2011: US08048423 (8 worldwide citation)
  3. Eric First, M.D.
    Eric R First: Stretch mark treatment. Allergan, Claude L Nassif, Stephen Donovan, Martin Voet, September 30, 2008: US07429386 (7 worldwide citation)
  4. Eric First, M.D.
    Eric R First: Methods for treating eye disorders. Allergan, Claude L Nassif, Stephen Donovan, Martin Voet, December 16, 2008: US07465458 (6 worldwide citation)
  5. Eric First, M.D.
    Eric R First: Methods and compositions for treating eye disorders. Allergan, Claude L Hassif, Stephen Donovan, Martin A Voet, May 22, 2007: US07220422 (6 worldwide citation)
  6. Eric First, M.D.
    Eric R First: Cosmetic neurotoxin compositions and methods. Allergan, Brigitte C Phan, Ted Chan, Debra Condino, February 11, 2014: US08647639 (5 worldwide citation)
  7. Eric First, M.D.
    Eric R First: Buttock deformity treatment. Allergan, Claude L Nassif, Stephen Donovan, Martin Voet, October 21, 2008: US07438921 (3 worldwide citation)
  8. Eric First, M.D.
    Eric R First: Methods for treating a buttock deformity. Allergan, Stephen Donovan, February 20, 2007: US07179474 (3 worldwide citation)
  9. Eric First, M.D.
    Eric R First, Ryan A Irvine: Methods for enhancing therapeutic effects of a neurotoxin. Allergan, Claude L Nassif, Kenton Abel, Debra Condino, November 2, 2010: US07824694 (3 worldwide citation)
  10. Eric First, M.D.
    Eric R First: Cosmetic neurotoxin compositions and methods. Allergan, Brigitte C Phan, Ted A Chan, Debra D Condino, June 16, 2015: US09056059

References: 13 (view full list)

  1. Keith L March, David R Hathaway, Robert L Wilensky: Method for delivery of smooth muscle cell inhibitors. Indiana University Foundation, Baker & Daniels, December 15, 1992: US05171217 (281 worldwide citation)
  2. Dennis D Dykstra, Abraham A Sidi: Method and device for pharmacological control of spasticity. Regents of the University of Minnesota, John W Bunch, June 12, 1990: US04932936 (60 worldwide citation)
  3. Gary E Borodic: Chemomodulation of curvature of the juvenile spine. Gary E Borodic, Edmund R Pitcher, Testa Hurwitz & Thibeault, October 1, 1991: US05053005 (53 worldwide citation)
  4. Gary E Borodic: Controlled administration of chemodenervating pharmaceuticals. Associated Synapse Biologics, Testa Hurwitz & Thibeault, March 29, 1994: US05298019 (31 worldwide citation)
  5. David Alker, Robert J Bass, Peter E Cross: 5,11-dihydrodibenzo[b,e][1,4]-thiazepines useful as gastro intestinal selective calcium antagonists. Pfizer, Peter C Richardson, J Trevor Lumb, A Dean Olson, December 10, 1991: US05071844 (8 worldwide citation)
  6. Jonathan D Fleischmann: Methods of treating interstitial cystitis and urethral syndrome. Case Western Reserve University, Fay Sharpe Beall Fagan Minnich & McKee, September 8, 1992: US05145859 (6 worldwide citation)
  7. Peter K Chiang, Michelle M Richard, Felipe N Padilla, Frank I Carroll, Philip Abraham: Azabicyloalkane phenyl substituted alkane carboxylates, their preparation and use as anticholinergic agents. The United States of America represented by the Secretary of the Army, Research Triangle Institute, Francis A Cooch, Werten F W Bellamy, December 15, 1987: US04713391 (5 worldwide citation)
  8. Richard J Bing: Relaxation of smooth vascular muscle. Huntington Medical Research Institutes, Ashen Golant Martin & Seldon, May 22, 1990: US04927629 (4 worldwide citation)
  9. William M Davis: Anti-spasmdoic agents having an acetylenic bond. United Pharmaceuticals, Austin R Miller, September 18, 1990: US04957941 (4 worldwide citation)
  10. William M Davis: Method of treating smooth muscle spasm. United Pharmaceuticals, Austin R Miller, February 16, 1988: US04725593 (3 worldwide citation)