A process is provided for controlling a ventilation procedure wherein a heliox ventilation system passes a breathing medium through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the heliox ventilation system are established. These desired ranges are input into a signal processor. Initial settings for the heliox ventilation system are then made such that the actual conditions which will initially occur during the heliox ventilation procedure fall within their respective desired ranges. Thereafter, the heliox ventilation procedure is commenced. During the heliox ventilation procedure, conditions which relate to the established ranges are continually monitored by appropriate sensors. The monitored information is also input into the signal processor. The signal processor is designed to compare the actually-occurring monitored conditions to their respective desired ranges and determine if there is a difference therebetween. If there is a difference, the signal processor generates signals which are designed to correct the discrepancy. These signals can be designed to trigger alarms which instruct an operator to make the appropriate adjustments and/or to activate a servo-controlled valving network. By practicing this invention, it is possible to maintain proper oxygenation levels in a patient ventilated with a heliox ventilation system while minimizing lung compliance and lung resistance levels.