05424186 is referenced by 542 patents and cites 8 patents.

A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a first predefined region of the substrate. The irradiation of a second predefined region of the substrate. The irradiation step removes a protecting group therefrom. The substrate is contacted with a first nucleotide to couple the nucleotide to the substrate in the first predefined region. By repeating these steps, an array of diverse oligonucleotides is formed on the substrate.

Title
Very large scale immobilized polymer synthesis
Application Number
362901
Publication Number
5424186
Application Date
December 6, 1991
Publication Date
June 13, 1995
Inventor
J Leighton Read
Palo Alto
CA, US
Michael C Pirrung
Durham
NC, US
Lubert Stryer
Stanford
CA, US
Stephen P A Fodor
Palo Alto
CA, US
Agent
Vern Norviel
Kevin R Kaster
Assignee
Affymax Technologies
AN
IPC
C07H 1/00
C12Q 1/68
View Original Source