A closure for sealing punctures in blood vessels utilizes a sheet adapted to conform to the inner surface of a blood vessel which sheet has a plurality of barbs attached to one surface. A pusher rod connects to the barbed surface. The sheet is pushed through a sheath that has been inserted into the puncture until the sheet is within the blood vessel. Then, the pusher rod pulls the sheet against the blood vessel inner wall to anchor it over the puncture. The pusher rod is then released from the sheet and both the sheath and pusher rod are removed completing the closure.