05382657 is referenced by 204 patents and cites 47 patents.

Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in vivo hydrolytic cleavage, have enhanced in vivo half life, and reduce the immunogenicity of the interferon while maintaining biological activity.

Title
Peg-interferon conjugates
Application Number
7/935770
Publication Number
5382657
Application Date
August 26, 1992
Publication Date
January 17, 1995
Inventor
Perry Rosen
North Caldwell
NJ, US
Carlo Nalin
Franklin Lakes
NJ, US
Robert Karasiewicz
Parsippany
NJ, US
Agent
Catherine R Roseman
William H Epstein
George M Gould
Assignee
Hoffmann La Roche
NJ, US
IPC
C07K 15/26
C07K 3/08
C07D 213/89
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