05378475 is referenced by 248 patents and cites 65 patents.

A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir comprising the effective agent; a first coating layer, which is essentially impermeable to the passage of the effective agent; and a second coating layer, which is permeable to the passage of the effective agent. The first coating layer covers at least a portion of the inner core; however, at least a small portion of the inner core is not coated with the first coating layer. The second coating layer essentially completely covers the first coating layer and the uncoated portion of the inner core.

Title
Sustained release drug delivery devices
Application Number
7/658695
Publication Number
5378475
Application Date
February 21, 1991
Publication Date
January 3, 1995
Inventor
Paul A Pearson
Lexington
KY, US
Paul Ashton
Lexington
KY, US
Thomas J Smith
Boston
MA, US
Agent
Burns Doane Swecker & Mathis
Assignee
University of Kentucky Research Foundation
KY, US
IPC
A61K 9/32
A61K 9/22
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