05330768 is referenced by 340 patents and cites 10 patents.

A new series of degradable polymeric matrices were prepared by blending polymers that degrade by hydrolysis such as poly(L-lactic acid)(PLA), and nonionic Pluronic.TM. surfactants, block copolymers of polyethyleneoxide (PEO) and polypropyleneoxide (PPO). The water content of the polymer blend films was controlled by mixing different types of block copolymers and by adjusting their amount. In aqueous solution, the blends revealed the typical liquid-crystalline phase transition of Pluronic.TM. polymers, suggesting the formation of a gel-like structure within the polymer skeleton. Poly(lactic acid) degradation rates were not affected by the blending procedure, although the hydration degree in these matrices was higher. When used as drug-releasing matrices, these blends extended protein release and minimized the initial protein burst, as compared to the pure polymer.

Title
Controlled drug delivery using polymer/pluronic blends
Application Number
7/726349
Publication Number
5330768
Application Date
July 5, 1991
Publication Date
July 19, 1994
Inventor
Robert S Langer
Newton
MA, US
Smadar Cohen
Petach-Tickva
IL
Tae G Park
Cambridge
MA, US
Agent
Kilpatrick & Cody
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61K 9/16
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