05326449 is referenced by 260 patents and cites 22 patents.

A sensor device for measuring the concentration of an analyte in solution is described. The device includes a composite membrane which incorporates a porous membrane containing an immobilized biologically-active protein and at least one other membrane. The other membrane may optionally be a blocking membrane, partly embedded in the porous membrane, which is adapted to exclude low molecular weight interfering species such as ascorbic acid. The other membrane may optionally be a protecting membrane which is useful for preventing high molecular species from fouling the porous membrane. Both a blocking membrane and a protecting membrane may be included in the composite membrane, simultaneously. The composite membrane is attached and reliably sealed to a housing by means of ultrasonic welding.

These features operate synergistically so that the device exhibits relatively fast response and recovery times, is reliably leak-proof, and may be constructed in relatively small sizes. A method of manufacturing the composite membrane is also provided.

Title
Composite membrane
Application Number
815426
Publication Number
5326449
Application Date
August 19, 1993
Publication Date
July 5, 1994
Inventor
David D Cunningham
Lakemoor
IL, US
Agent
Robert E Wexler
Assignee
Abbott Laboratories
IL, US
IPC
G01N 27/26
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