The present invention allows operating room personnel to easily and expeditiously drape an endoscope. The present invention is preferably made of polyethylene or some other suitable plastic material. The cylindrical drape cartridge itself acts as a shroud and functions as a sterile barrier. The drape cartridge consists of an inner and outer polyethylene tube which retains the polyethylene drape within its walls. The proximal end of the cartridge is mechanically secured by detents and a chamfer that encase a corrugated pattern of the polyethylene drape. The inner tube acts as a mandrel, allowing the drape to be compressed in a manner that accommodates the various lengths of required draping while lessening the bulk of the draping system.