05321012 is referenced by 186 patents and cites 60 patents.

Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.

Title
Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
Application Number
10583
Publication Number
5321012
Application Date
April 6, 1993
Publication Date
June 14, 1994
Inventor
John W Lyle
Belmar
NJ, US
Jianren Mao
Richmond
VA, US
Donald D Price
Richmond
VA, US
David J Mayer
Richmond
VA, US
Agent
Dilworth & Barrese
Assignee
Virginia Commonwealth University Medical College
VA, US
IPC
A61K 31/44
A61K 31/54
A61K 31/55
A61K 31/70
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