05317010 is referenced by 44 patents and cites 3 patents.

Analogues of bovine and human parathyroid hormone, wherein twenty-fifth, twenty-six and twenty-seventh positions of the natural hormone, Arg-Lys-Lys- each have been substituted with Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val have been found to retain bone cell effect with minimal effects on blood pressure and smooth muscle, including cardiac muscle. It has further been found that this effect can be obtained by using a synthetic PTH containing only the first 34 amino acids of PTH, with substitution at the twenty-fifth, twenty-sixth and twenty-seventh amino acids as described. These analogues of PTH also are effective in the treatment of osteoporosis and other bone diseases.

Title
Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
Application Number
7/773098
Publication Number
5317010
Application Date
October 10, 1991
Publication Date
May 31, 1994
Inventor
Jie Shan
Edmonton
CA
Peter K T Pang
University of Alberta, Dept. of Physiology, 7-55 Medical Science Bldg., Edmonton
CA
Agent
Nikaido Marmelstein Murray & Oram
Assignee
Peter K T Pang
CA
IPC
C07K 7/10
A61K 37/36
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