05314874 is referenced by 49 patents and cites 15 patents.

The present invention provides an intracorporeally injectable non-toxic composition of atelocollagen having an excellent, long-lasting skin swelling effect due to its low viscosity, good fluidity, easy injectability and low antigenicity (without calcification) properties. The composition is prepared by treating an aqueous suspension of atelocollagen with a buffer for physiological conditions. The suspension can have atelocollagen content of 55 to 75 mg/ml, where approximately 20 to 100% by weight of atelocollagen is cross-linked with a polyepoxy compound.

Title
Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen
Application Number
7/872722
Publication Number
5314874
Application Date
April 15, 1992
Publication Date
May 24, 1994
Inventor
Tadatomo Kawai
Tokyo
JP
Teruo Miyata
Tokyo
JP
Agent
Varndell Legal Group
Assignee
Koken
JP
IPC
A61K 7/12
C07K 15/20
C08B 37/10
A61L 33/00
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