05310469 is referenced by 313 patents and cites 20 patents.

A sensor for measuring the concentration of an analyte in a solution is disclosed. The sensor may be adapted for use as either an amperometric or a potentiometric sensor. It includes a membrane having a biologically active protein immobilized within. The membrane is attached and reliably sealed to a housing by means of ultrasonic welding, either directly or indirectly. Further, the membrane may be compressed to a fraction of its original dimensions. Metallic parts of the device may, optionally, be physically isolated from the sample solution to reduce corrosion. These features operate synergistically so that the claimed device exhibits relatively fast response and recovery times, is reliably leak-proof, and may be constructed in relatively small sizes.

Title
Biosensor with a membrane containing biologically active material
Application Number
7/815423
Publication Number
5310469
Application Date
December 31, 1991
Publication Date
May 10, 1994
Inventor
Neal T Sleszynski
Kenosha
WI, US
Thomas G Schapira
Bristol
WI, US
Laura S Morici
Cary
IL, US
Kenneth S Johnson
Buffalo Grove
IL, US
Timothy P Henning
Vernon Hills
IL, US
R Hayes Helgren
Mundelein
IL, US
Jill M Geist
Ingleside
IL, US
Susan B Brontman
Buffalo Grove
IL, US
David D Cunningham
Lakemoor
IL, US
Agent
Robert E Wexler
Assignee
Abbott Laboratories
IL, US
IPC
G01N 27/26
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