A computerized method and system for reducing the number of false-positive detections of nodule candidates in the detection of abnormalities in digital chest radiography. The image is initially subjected to an image difference technique where the detection sensitivity is increased so as to avoid missing small nodules which might otherwise go undetected. Such a technique tends to increase the number of false-positives, however, leading to possible incorrect diagnoses of the radiographs. To reduce the number of false-positives, feature extraction techniques are applied to grown regions around the nodule candidates, in order to provide computer generated information concerning the candidates. A data base of parameters common to false-positives is compared to calculated parameters of a candidate of interest. The candidates with grown region parameters within the data base range common to false-positives are eliminated as being probable false-positive detections due to normal background anatomical features.