05281698 is referenced by 226 patents and cites 3 patents.

The present invention is a process for preparing an activated ester of polyethylene glycol or a polyoxyethylated polyol. After the activated ester is prepared, it can be reacted with a protein to form a polymer/protein conjugate. Conjugation with a polymer can reduce the protein's immunogenicity, increase its solubility, and increase its circulating in vivo half-life. Preferred proteins are IL-2, CSFs, and interferons.

Title
Preparation of an activated polymer ester for protein conjugation
Application Number
7/734749
Publication Number
5281698
Application Date
July 23, 1991
Publication Date
January 25, 1994
Inventor
Danute E Nitecki
Berkeley
CA, US
Agent
Philip L McGarrigle Jr
Kenneth M Goldman
Grant D Green
Assignee
Cetus Oncology Corporation
CA, US
IPC
C07K 15/26
C07K 15/06
C07K 3/08
C07D 207/404
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