A plastic autoclave enclosure for retaining and storing medical instruments and apparata which must be autoclaved includes a molded tray, a molded lid and a pair of oppositely disposed slide latches which are used to secure the molded lid to the molded tray. The molded tray has an outwardly extending flange and disposed therein a pair of spaced-apart keyhole slots. The slide latches are attached to opposite ends of the molded lid and include a protruding pin portion from each latch which has an enlarged head and this enlarged head is received by the corresponding keyhole slot. The base of the molded tray is configured with two spaced-apart ribs and the molded lid has a pair of spaced-apart ribs which define the top surface into three generally rectangular areas. The spacing and length dimension of the tray ribs is such that the base of the tray may be stacked onto the top of the lid thereby allowing a plurality of autoclave enclosures to be stacked one on top of the other.